【 Veterinary drug name 】
Generic name: Albendazole tablets
English name: Albendazole Tablets

【 Main ingredient 】 Albendazole
[Sexual appearance] This product is a white tablet.
【 Pharmacological action 】 Pharmacodynamics Albendazole is benzimidazole, which has a broad spectrum repellent effect. Nematodes are sensitive to it, and it also has a strong effect on tapeworms and flukes (but requires a larger dose), but it is not effective against schistosoma. The main mechanism of action is binding with the nematode microtubulin. Albendazole binds to tubulin and prevents it from polymerizing with A-tubulin to form microtubules. Microtubules are the basic structural unit of many organelles and are necessary for cell reproduction processes such as mitosis, protein assembly and energy metabolism. The affinity of albendazole to C. elegans microtubulin is significantly higher than that of mammalian microtubulin, so the toxicity to mammalian microtubulin is minimal. This product not only has a strong effect on adult insects, but also has a strong effect on immature insects and larvae, and has a killing effect on eggs.
Pharmacokinetics Albendazole is a benzimidazole that is well absorbed internally. Cattle can absorb up to 50% of the dose from the gastrointestinal tract. 47% of the drug metabolites of the internal dose can be recovered from the urine within 9 days. After internal administration in sheep, because it is quickly metabolized to albendazole sulphoxide (the main active metabolite of deworming), the protodrug cannot be detected in blood or can only be detected for a short time. At 20 hours after administration, metabolites albendazole sulfoxide and albendazole sulfoxide reached plasma drug peak concentrations. The elimination half-lives of sulfoxide metabolites in cattle, sheep, pigs, rabbits and chickens are 20.5, 7.7-9.0, 5.9, 4.1 and 4.3 hours, respectively. The elimination half-lives of sulfoxide metabolites are 11.6, 11.8, 9.2, 9.6 and 2.5 hours, respectively. In addition to sulfoxide and sulfone, there are hydroxylation, hydrolysis and binding products, which are excreted from the body through bile juice.
【 Drug interaction 】 The combination of albendazole and praziquantel can increase the blood concentration of albendazole.
【 Function and use 】 Antihelminthic drug. Used for nematodiasis, tapeworm disease and fluoriasis in livestock and poultry.
(1) Dogs taking 50mg/kg twice a day will gradually produce anorexia.
(2) The cat may have mild lethargy, depression, anorexia and other symptoms, when treated with this product and paragonimiasis, there is a phenomenon of resistance.
(3) Can cause aplastic anemia in dogs and cats.
(4) Teratogenic and embryonic toxic effects on animals in early pregnancy:
[Precautions] (1) The lactation period of cows is prohibited.
(2) Do not use within 45 days before the gestation period of cattle and sheep.
[Drug withdrawal period] Cattle 14 days, sheep 4 days, pig 7 days, poultry 4 days; Discard period of 60 hours.
【 Storage 】 Sealed storage.

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