【 Veterinary drug name 】

General name: Lincomycin hydrochloride soluble powder

Product Name:

English name: Lincomycin Hydrochloride Soluble Porder

Chinese Pinyin :Yansuan Linkemeisu kerongxingfen

【 Main ingredient 】 Lincohcl 

【 Properties 】 This product is white or white powder.

[Pharmacological effects] Pharmacodynamics Lincomycin belongs to lincoamine class antibacterial drugs, is a bacteriostatic agent, sensitive bacteria include Staphylococcus aureus (including cyanin-resistant strains), streptococcus, pneumococcus, icterobacterium, erysipelas suis, some mycoplasma (mycoplasma suis pneumoniae, mycoplasma suis), Mycoplasma suis, Mycoplasma suis articularis), Spirochaetes leptospira and anaerobic bacteria (such as Fusobacterium, Clostridium tetanus, aeromogenes and most actinomyces). It mainly acts on the 50S subunit of the bacterial ribosome, and plays an antibacterial role by inhibiting the extension of the peptide chain and affecting the synthesis of proteins. Pharmacokinetic absorption in animals is rapid but incomplete, and bioavailability in pigs is 20%-50%. Most animals take it internally for 1 hour to reach peak levels. It is widely distributed in various body fluids and tissues (including bone), among which the concentration of liver and kidney is the highest, and the concentration of tissue drugs is several times higher than that of serum. It can enter the placenta, but it does not easily cross the blood-brain barrier, and the drug does not reach an effective concentration in the cerebrospinal fluid during inflammation.

It can be distributed to milk, and the concentration in milk is the same as that in plasma. section

The drug is metabolized in the liver, and the drug form and its metabolites are excreted through bile, urine and milk. Fecal excretion can be delayed for several days, so it has an inhibitory effect on intestinal sensitive microorganisms.

[Drug interaction 11] When combined with gentamicin, it has a synergistic effect on gram-positive bacteria such as staphylococcus and streptococcus. 2) When combined with aminoglycosides and polypeptide antibiotics, it may enhance the blocking effect on neuromuscular junction. Combined with erythromycin has antagonistic effect, because of the same site of action, Danerythromycin has stronger affinity to the 50S subunit of bacterial ribosomes than this product. (3) It is not suitable to be combined with anti-fouling drugs that inhibit intestinal and gastrointestinal peristalsis and contain white taos.

(4) There is incompatibility with kanamycin and neomycin.

[Indication] For gram-positive bacteria infection, especially penicillin-resistant and sensitive bacterial infection, such as staphylococcal disease, streptococcal disease, mastitis, etc., can also be used for swine treponemosis and mycoplasma infection caused by swine asthma.

[Usage and dosage J measured by Linke toxin. Mixed drink: 40~70mg per 1L of water for pig for 7 days; 150mg for chicken.

For 5 to 10 days.

[Adverse reaction] has neuromuscular blocking effect.

[Precautions] Gastrointestinal dysfunction may occur in pigs after medication.

[Drug withdrawal period] Pig 6 days.

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